Comparison of Plasmid yield between L.B. and using Molasses as a medium

During the initial studies I have found that the molasses may be a good alternative to costly L.B media where one can manipulate the C/N ratio as per requirement of cell. Molasses is one of the best alternatives as it is cheap and can be easily manipulated. Escherichia coli is a bacterium that is commonly found in the lower intestine of warm-blooded animals. it is possible to produce vaccine by molasses medium. The paper is opening a new face of study

RIZATRIPTAN BENZOATE LOADED NATURAL POLYSACCHARIDE BASED MICROSPHERES FOR NASAL DRUG DELIVERY SYSTEM

Objective: The objective of this research was to formulate and evaluate the different grades of rizatriptan benzoate loaded polysaccharide based microspheres for the nasal drug delivery system.Methods: The polysaccharide was extracted from the seed of Trigonella foenum-graecum and microspheres were prepared by emulsification, followed by crosslinking using epichlorohydrin. A 32 full factorial design was employed in formulating the microspheres with polymer concentration (X1), and stirring rate (X2) as independent variables and particle size (Y1) and entrapment efficiency (Y2) were dependent variables.Results: The microspheres were discrete and free-flowing. The mean particle size (Y1) of microspheres ranged from 40.82+12 µm to 62.48+0.41 µm and the encapsulation efficiency (Y2) was found to be increased from 60.7+0.2% to 79.22+0.2% as the drug polysaccharide ratio increased. A 32 full factorial design confirmed that the X1 and X2 both effect on particle size whereas X1 alone effect on entrapment efficiency. SEM revealed the smooth spherical surface of microspheres whereas kinetic model revealed that drug release followed the case II transport. FTIR indicated good compatibility of the excipients with rizatriptan benzoate. Stability studies were carried out for formulation F7 at 4°C ambient, 25+2°C/60+5%, 40+2°C/75+5% relative humidity revealed that the physical drug appearance, entrapment efficiency were within the permissible limits.Conclusion: The result obtained in this research work indicate a promising potential of control release rizatriptan benzoate loaded microspheres whereas the Trigonella foenum-graecum polysaccharide used as rate controlling polymer for the effective treatment of migraine patients

Binary and Ternary Fragmentation Analysis of 252Cf Nucleus using Different Nuclear Radii

Pioneering study reveals that a radioactive nucleus may split into two or three fragments and the phenomena are known as binary fission and ternary fission respectively. In order to understand the nuclear stability and related structure aspects, it is of huge interest to explore the fragmentation behavior of a radioactive nucleus in binary and ternary decay modes. In view of this, Binary and ternary fission analysis of 252Cf nucleus is carried out using quantum mechanical fragmentation theory (QMFT). The nuclear potential and Coulomb potential are estimated using different versions of radius vector. The fragmentation structure is found to be independent to the choice of fragment radius for binary as wellas ternary decay paths. The deformation effect is included up to quadrupole (β2) with optimum cold orientations and their influence is explored within binary splitting mode. Moreover, the most probable fission channels explore the role of magic shell effects in binary and ternary fission modes.

Identifying supply chain strategies of firms with best supply chain performance

Thesis (S.M. in System Design and Management)--Massachusetts Institute of Technology, Engineering Systems Division, System Design and Management Program, 2010.Cataloged from PDF version of thesis.Includes bibliographical references.The Global Business Climate has been rapidly changing and has become more competitive. Enterprise now not only needs to operate at a lower cost to compete, it must also develop its own core competencies to distinguish itself from competitors and stand out in the market. The focus has now moved towards improving operational efficiency to stay competitive. Supply Chain is one of the important areas which almost every company is currently working to improve their operation efficiency. Improving operational efficiency in supply chain has three aspects including improving supply chain strategies, following better supply chain management practices, and aligning supply chain strategy with overall business strategy. Our thesis research objective is to understand what policies, capabilities, and strategies of an enterprises leads to best supply chain management. The research is cross industry, across all supply chain management domain and will shed light on what makes companies "best performer" by identifying and exploring the distinctive capabilities required in five key supply chain domains that contribute to high performance in the relevant operational metrics. The domains studied in our research are supply chain planning, fulfillment, service management, product lifecycle management, and, manufacturing. Another objective of our thesis is to relate domain performance of the firm with the firm's value proposition. The three value propositions considered in the thesis are product leadership/innovation, cost competitiveness, and customer service.by Nitin Gulati & Amar Sharma.S.M.in System Design and Managemen

Placement of Distributed Generation for Improvement of Voltage Profile in Distribution System

Distributed Generation is an approach that employs small-scale technologies to produce electricity close to the end users of power.When total system load is more than its generation capacity that makes relieving of load on the feeders not possible and hence voltage profile of the system will not be improved to the required level. In order to meet required level of load demand, DG units are integrated in distribution network to improve voltage profile, to provide more reliable and less uninterrupted power supply. Voltage stability is an important problem in the emerging world of technologies and development, the main objectives in operating an electric power system is to maintain a proper voltage level thought DG. Voltage Stability Index method is to be used for determining DG placement candidates. A Voltage Stability Index method is to be executed on the system and the bus with a minimum voltage at the collapse point is defined as the most sensitive bus to voltage collapse. This bus is to be selected as a candidate for DG placement